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研究表明,对特殊食物的口味是由基因决定的

The reasons why people love certain foods and turn their noses up at others, has to do with more than their cultures or even their taste buds… their genes play a significant role too, 一项新的研究表明.

鳄梨食物的碗
鳄梨和鲑鱼的食物碗. 信贷,盖蒂图片社.

的遗传变异

研究ers have identified hundreds of genetic variants – differences in peoples’ genetic make-up – linked with their liking for specific foods, 包括那些喜欢吃大料的, 鳄梨, 辣椒, 牛排, 多油的鱼等等.

在最大规模的食物喜好基因研究中, scientists from the University of Edinburgh and 人类Technopole, 米兰研究了150多个,000 individuals’ fondness for 137 different foods and beverages.

食物的喜好

They found 401 genetic variants that influenced which foods participants liked. Many of these variants affected more than one food-liking trait and some only one particular food. 例如, some genetic variants were linked with an enjoyment for only salmon, while other groups of variants increased a liking for oily fish or all fish in general.

Map

The team used questionnaires and genetic analysis to develop a so-called ‘food map’ – showing how participants’ appreciation of groups of food and specific flavours are influenced by similar genetic variants.

The map reveals three main clusters of foods that share a similar genetic component.

One group is made up of high-calorie and highly palatable foods such as meat, dairy and desserts; another group consists of strong-tasting foods that are known as ‘acquired’, including alcohol and pungent vegetables; and a third group contains low-calorie foods such as fruit and vegetables.

健康特征

研究ers discovered that the three food groups also shared genes known to be associated with distinct health traits.

例如, the highly palatable foods are influenced by the same genetic variants also linked with obesity and lower levels of physical activity. A higher liking for fruit and vegetables is influenced by the same variants that are related to higher levels of physical activity. And higher liking for ‘acquired’ tastes are genetically associated with a healthier 胆固醇 profile and higher physical activity but also a higher likelihood of smoking and alcohol intake. 

令人惊讶的发现

然而, the team was surprised to find genetic differences between liking subsets of foods within the same category. 例如, they expected that genetic variants relating to liking vegetables would be consistent across all types of vegetables, meaning that people who liked one vegetable would like them all.

而不是, they found a weak relationship between the genes associated with cooked and salad vegetables and the genes linked with 味道较重的蔬菜,如菠菜和芦笋.

大脑模式

最后, the team found little correlation between the genes linked with high-calorie foods and the other two groups, suggesting there are independent biological processes underlying the liking for highly palatable foods.

MRI scans found a correlation between the part of the brain involved with pleasure processing and the genetic variation linked with highly palatable foods, whilst the low calorie and strong tasting foods correlated with areas of the brain associated with decision making.

Experts say that by having a better understanding of what drives peoples’ food choices, their research could help to develop healthier and more accepted food products, improve dietary interventions and potentially lead to medications to support extremely obese people lose weight.

The research was funded by the Medical 研究 Council and published in Nature Communications.

This is a great example of applying complex statistical methods to large genetic datasets in order to reveal new biology, in this case the underlying basis of what we like to eat and how that is structured hierarchically, 从单个的食物到大量的食物.

吉姆·威尔逊教授Personal Chair of Human Genetics, University of Edinburgh

One of the important messages from this paper is that although taste receptors and thus taste is important in determining which foods you like, it is in fact what happens in your brain which is driving what we observe. “Another important observation is that the main division of preferences is not between savoury and sweet foods, 这可能是意料之中的, but between highly pleasurable and high calorie foods and those for which taste needs to be learned. This difference is reflected in the regions of the brain involved in their liking and it strongly points to an underlying biological mechanism.

博士尼古拉PirastuSenior Manager Biostatistics Unit, 人类Technopole, Milan

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人类遗传学小组   

人类Technopole   

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